Wondering what the best heartworm medications are for your dog? Discover our top 10 picks for trusted brands that offer strong protection, easy monthly routines, and flavors dogs love.
Keeping your dog safe from heartworm disease is one of the most important things you can do. The right medication makes it simple and stress-free.
I’ve seen how much peace of mind these chews bring. Dogs love the flavors. Owners love the easy monthly routine. Everyone loves the strong protection.
Choosing the best option can feel tricky. But with clear guidance, it’s simple. You’ll know which trusted brands give your dog the safest care. Read on to find the perfect fit.
List of Top 10 Heartworm Medications
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TRI-HEART PLUS Chewable Tablet for Dogs, up to 25 lbs (Blue Box), 6 Chewable Tablets, 6-Month Supply |
This product is perfect for dog owners who want to protect their small dogs (up to 25 lbs) from heartworms, roundworms, and hookworms. It’s easy to give, beef-flavored, and safe for dogs with beef allergies. |
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TRI-HEART PLUS Chewable Tablet for Dogs, 26-50 lbs (Green Box), 6 Chewable Tablets, 6-Month Supply |
This is perfect for dog owners who want easy, safe, and tasty protection against heartworms, roundworms, and hookworms. It’s made for dogs who need monthly care that’s simple and stress-free. |
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HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs 51 -100 lbs (Brown Box) 1 Month Supply of Chews (Heartworm Disease Preventive) |
This product is perfect for dog owners who want to protect their large dogs from heartworm disease and other parasites. It’s easy to use and dogs love the real-beef flavor. |
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HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 1 Month Supply of Chews (Heartworm Disease Preventive) |
This is perfect for dog owners who want an easy, tasty way to keep their small pups safe. It’s made for anyone who wants trusted protection against heartworms, roundworms, and hookworms—all in a chew dogs actually enjoy. |
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NexGard Plus (afoxolaner, moxidectin, and pyrantel) Flea and Tick Protection & Heartworm Preventive for Dogs Soft Beef Flavored Chewables, 33.1-66 lbs. (Purple) 3 Chews (3 Month Supply) |
This product is perfect for dog owners who want simple, all-in-one protection for their pets. It’s ideal for dogs weighing 33.1-66 lbs and offers flea, tick, heartworm, and worm control in one monthly chew. |
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Interceptor Plus Prevention for Heartworm + 4 Other Worms for Dogs 8.1-25 lbs. | 1 Chew, 1-Month Supply |
This is perfect for dog owners who want easy, tasty protection against heartworm and 4 other worms every month. It’s made for pups who love chicken flavor and need full coverage from the risks in parks, trails, and backyards. |
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Interceptor Plus Prevention for Heartworm + 4 Other Worms for Dogs 25.1-50 lbs. | 1 Chew, 1-Month Supply |
This product is perfect for dog owners who want complete protection against heartworm and other common worms. It’s easy to use and tasty for dogs, making it ideal for monthly care. |
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MilbeGuard Flavored Tablet for Dogs (11-25 lbs) and Cats (1.5-6 lbs) – 6 ct |
Perfect for dog owners and cat parents who want an easy, safe, and vet-backed way to protect their pets. Simple monthly tablet with trusted protection that’s FDA-approved and flavored for pets. |
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BRAVECTO PLUS Topical Solution for Cats, Flea, Tick & Heartworm, 2 Months Supply, 6.2-13.8 lbs., Blue Box |
BRAVECTO Plus is perfect for cat owners who want fast, safe, and long-lasting protection against fleas, ticks, and heartworms. It’s ideal for indoor and outdoor cats weighing 6.2-13.8 lbs, offering up to 2 months of coverage with just one easy dose. |
Detailed Reviews
Discover the Best Heartworm Medications with our expert-reviewed guide. Each product is carefully chosen for its safety, effectiveness, and value. Simple, clear insights will help you pick the perfect protection for your pet.
1. TRI-HEART PLUS Chewable Tablet for Dogs, up to 25 lbs (Blue Box), 6 Chewable Tablets, 6-Month Supply
Keep your small dog safe with TRI-HEART PLUS Chewable Tablets. These easy-to-give, beef-flavored tablets protect against heartworm disease, roundworms, and hookworms.
Monthly use means year-round protection. It’s simple. It’s safe. And your dog will love it.
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Perfect For:
This product is perfect for dog owners who want to protect their small dogs (up to 25 lbs) from heartworms, roundworms, and hookworms. It’s easy to give, beef-flavored, and safe for dogs with beef allergies.
Ready to Purchase?
2. TRI-HEART PLUS Chewable Tablet for Dogs, 26-50 lbs (Green Box), 6 Chewable Tablets, 6-Month Supply
Keep your dog safe with TRI-HEART PLUS Chewable Tablets. This easy, monthly treatment helps prevent heartworm disease and controls roundworms and hookworms.
It stops heartworm larvae. It protects your dog’s heart. It keeps your dog healthy all year.
Dogs love the beef-flavored chewable. It’s simple to give and safe even for dogs with beef allergies. Strong protection, easy care.
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Perfect For:
This is perfect for dog owners who want easy, safe, and tasty protection against heartworms, roundworms, and hookworms. It’s made for dogs who need monthly care that’s simple and stress-free.
Ready to Purchase?
3. HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs 51 -100 lbs (Brown Box) 1 Month Supply of Chews (Heartworm Disease Preventive)
HEARTGARD® Plus is a vet-recommended way to keep your dog safe. It prevents heartworm disease with just one chew. Your dog will love the real-beef flavor.
This once-a-month chew also treats roundworms and hookworms. It’s a trusted brand used over 2.5 billion times.
Dogs love the taste, and it’s easy to give. Protect your dog with HEARTGARD® Plus today.
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Perfect For:
This product is perfect for dog owners who want to protect their large dogs from heartworm disease and other parasites. It’s easy to use and dogs love the real-beef flavor.
Ready to Purchase?
4. HEARTGARD® Plus (ivermectin/pyrantel) Real-Beef Chewables for Dogs up to 25 lbs (Blue Box) 1 Month Supply of Chews (Heartworm Disease Preventive)
Protect your small dog with HEARTGARD® Plus. This vet-recommended chew helps stop heartworm disease before it starts.
It also fights roundworms and hookworms. Trusted over 2.5 billion times, it’s proven care you can count on.
Dogs love the real-beef taste. You give it once a month. Easy. Effective. Delicious.
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Perfect For:
This is perfect for dog owners who want an easy, tasty way to keep their small pups safe. It’s made for anyone who wants trusted protection against heartworms, roundworms, and hookworms—all in a chew dogs actually enjoy.
Ready to Purchase?
5. NexGard Plus (afoxolaner, moxidectin, and pyrantel) Flea and Tick Protection & Heartworm Preventive for Dogs Soft Beef Flavored Chewables, 33.1-66 lbs. (Purple) 3 Chews (3 Month Supply)
NexGard Plus is a monthly chewable for dogs weighing 33.1-66 lbs. It comes in a beef flavor that dogs love. Each pack provides three months of protection.
This product kills fleas and ticks and prevents heartworm disease. It also treats hookworms and roundworms. It’s a convenient, all-in-one solution.
With NexGard Plus, you get broad parasite protection. It’s easy to give and dogs enjoy the taste. Keep your dog happy and healthy with this simple monthly dose.
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Perfect For:
This product is perfect for dog owners who want simple, all-in-one protection for their pets. It’s ideal for dogs weighing 33.1-66 lbs and offers flea, tick, heartworm, and worm control in one monthly chew.
Ready to Purchase?
6. Interceptor Plus Prevention for Heartworm + 4 Other Worms for Dogs 8.1-25 lbs. | 1 Chew, 1-Month Supply
Strong protection. Easy chew. Happy dog.
Interceptor PLUS stops heartworm disease and fights hookworm, roundworm, whipworm, and tapeworm. One tasty chicken-flavored chew gives a full month of safety.
Dogs love the flavor. Owners love the peace of mind.
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Perfect For:
This is perfect for dog owners who want easy, tasty protection against heartworm and 4 other worms every month. It’s made for pups who love chicken flavor and need full coverage from the risks in parks, trails, and backyards.
Ready to Purchase?
7. Interceptor Plus Prevention for Heartworm + 4 Other Worms for Dogs 25.1-50 lbs. | 1 Chew, 1-Month Supply
Interceptor Plus is a monthly chew that keeps your dog safe from heartworm and four other worms. It’s a tasty, chicken-flavored treat your dog will love, making it easy to give.
This chew protects for a full month, covering worms found in parks, trails, and backyards. It also treats and controls hookworm, roundworm, whipworm, and tapeworm.
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Perfect For:
This product is perfect for dog owners who want complete protection against heartworm and other common worms. It’s easy to use and tasty for dogs, making it ideal for monthly care.
Ready to Purchase?
8. MilbeGuard Flavored Tablet for Dogs (11-25 lbs) and Cats (1.5-6 lbs) – 6 ct
MilbeGuard is a monthly tablet for dogs and cats. It comes in four sizes and color-coded packages.
This product is FDA-approved and veterinarian-backed. It has a 30-year history of safe use.
Meat-free, beef-flavored, and easy to use. Protects pets with one tablet.
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Perfect For:
Perfect for dog owners and cat parents who want an easy, safe, and vet-backed way to protect their pets. Simple monthly tablet with trusted protection that’s FDA-approved and flavored for pets.
Ready to Purchase?
9. BRAVECTO PLUS Topical Solution for Cats, Flea, Tick & Heartworm, 2 Months Supply, 6.2-13.8 lbs., Blue Box
Keep your cat safe with BRAVECTO PLUS Topical Solution. One simple dose gives fast-acting protection that lasts nearly 2X longer than other treatments.
Your cat gets 2 months of flea & tick defense. The Twist’n’Use applicator makes it easy. Even indoor cats can get fleas and ticks. Stay ahead with BRAVECTO PLUS.
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Perfect For:
BRAVECTO Plus is perfect for cat owners who want fast, safe, and long-lasting protection against fleas, ticks, and heartworms. It’s ideal for indoor and outdoor cats weighing 6.2-13.8 lbs, offering up to 2 months of coverage with just one easy dose.
Ready to Purchase?
Buying Guide
Keeping your dog safe from heartworm disease is vital. The right medication makes it simple and stress-free.
Choosing the best heartworm medication can feel tricky, but with clear guidance, it’s easy. Here’s what to consider:
- Dog’s Weight: Pick a product that matches your dog’s weight range. Most medications come in sizes for small, medium, or large dogs.
- Flavor: Dogs love tasty chews. Look for beef-flavored or chicken-flavored options to make it a treat.
- Protection Level: Some products only prevent heartworm, while others also fight fleas, ticks, and other worms. Choose based on your dog’s needs.
- Ease of Use: Monthly chews are simple and stress-free. Topical solutions are also an option if your dog prefers them.
- Brand Trust: Go for vet-recommended or FDA-approved brands like HEARTGARD® Plus or NexGard Plus for proven safety.
- Allergies: If your dog has beef allergies, look for meat-free or alternative flavor options.
- Supply Duration: Some packs offer 6-month or 3-month supplies, saving you time and money.
With these factors in mind, you’ll find the perfect heartworm medication to keep your dog happy and healthy.